Emerging role of SENP1 in tumorigenesis and cancer therapy

作者：Min Lin, Man Zhang, Yi Bei, Jinchi Chen, Siqi Wen, Ruiqi Chen, Tianyu Chen, Li Zhao · 发表于：Frontiers in Pharmacology · 年份：2024 · DOI：10.3389/fphar.2024.1354323 · 被引用次数：11 · 研究领域：Ubiquitin and proteasome pathways、ATP Synthase and ATPases Research、Cancer Research and Treatments

Acting as a cysteine protease, small ubiquitin-like modifier (SUMO)/sentrin-specific protease1 (SENP1) involved in multiple physiological and pathological processes through processing the precursor SUMO protein into mature form and deSUMOylating target protein. It has been reported that SENP1 is highly expressed and plays a carcinogenic role in various cancers. In this paper, we mainly explore the function and mechanism of SENP1 in tumor cell proliferation, apoptosis, invasion, metastasis, stemness, angiogenesis, metabolism and drug resistance. Furthermore, the research progress of SENP1 inhibitors for cancer treatment is introduced. This study aims to provide theoretical references for cancer therapy by targeting SENP1.