The omicron BA.2.86 subvariant as a new serotype of SARS-CoV-2

作者：Pei Du, Chunli Wu, Shixiong Hu, Rui Fan, George F. Gao, Qihui Wang · 发表于：The Lancet Microbe · 年份：2024 · DOI：10.1016/s2666-5247(23)00411-1 · 被引用次数：23 · 研究领域：SARS-CoV-2 and COVID-19 Research、Animal Virus Infections Studies、vaccines and immunoinformatics approaches

The evolution of SARS-CoV-2 has resulted in the emergence of multiple serotypes1Hu S Wu C Wu X et al.Classification of five SARS-CoV-2 serotypes based on RBD antigenicities.Sci Bull (Beijing). 2023; 68: 3003-3012Crossref PubMed Scopus (0) Google Scholar,2Tan CW Zhu F Chia WN et al.Distinctive serotypes of SARS-related coronaviruses defined by convalescent sera from unvaccinated individuals.hLife. 2023; 1: 26-34Crossref Google Scholar capable of evading vaccines based on the SARS-CoV-2 prototype.3Xu K Fan C Han Y Dai L Gao GF Immunogenicity, efficacy and safety of COVID-19 vaccines: an update of data published by 31 December 2021.Int Immunol. 2022; 34: 595-607Crossref PubMed Scopus (12) Google Scholar Classifying SARS-CoV-2 serotypes can guide antigen selection for development of broad-spectrum vaccines and neutralising antibodies. Previously, we classified five SARS-CoV-2 serotypes (I to V) on the basis of the receptor binding domain (RBD) antigenicity of 23 variants, encompassing the pre-omicron variants and omicron and its subvariants.1Hu S Wu C Wu X et al.Classification of five SARS-CoV-2 serotypes based on RBD antigenicities.Sci Bull (Beijing). 2023; 68: 3003-3012Crossref PubMed Scopus (0) Google Scholar Serotype I includes all selected pre-omicron variants, whereas omicron and its subvariants are distributed across serotypes II to V on the basis of their evolutionary stages. In recent months, several novel omicron subvariants—XBB.1.16, EG.5, FL.1.5.1, and BA.2.86—have be...