Academic achievement at ages 11 and 16 in children born with congenital anomalies in England: A multi‐registry linked cohort study

作者：Svetlana V. Glinianaia, Joachim Tan, Joan K. Morris, J L Brigden, Hannah Evans, Maria Loane, Amanda J. Neville, Judith Rankin · 发表于：Paediatric and Perinatal Epidemiology · 年份：2024 · DOI：10.1111/ppe.13049 · 被引用次数：6 · 研究领域：Prenatal Screening and Diagnostics、Family and Disability Support Research、Williams Syndrome Research

BACKGROUND: Children born with major congenital anomalies (CAs) have lower academic achievement compared with their peers, but the existing evidence is restricted to a number of specific CAs. OBJECTIVES: To investigate academic outcomes at ages 11 and 16 in children with major isolated structural CAs and children with Down or Turner syndromes. METHODS: This population-based cohort study linked data on approximately 11,000 school-aged children born with major CAs in 1994-2004 registered by four regional CA registries in England with education data from the National Pupil Database (NPD). The comparison group was a random sample of children without major CAs from the background population recorded in the NPD that were frequency matched (5:1) to children with CAs by birth year, sex and geographical area. RESULTS: Overall, 71.9%, 73.0% and 80.9% of children with isolated structural CAs achieved the expected attainment level at age 11 compared to 78.3%, 80.6% and 86.7% of the comparison group in English language, Mathematics and Science, respectively. Children with nervous system CAs as a whole had the lowest proportion who achieved the expected attainment at age 11. At age 16, 46.9% of children with CAs achieved the expected level compared to 52.5% of their peers. Major CAs were associated with being up to 9% (95% confidence interval [CI] 8%, 11%) and 12% (95% CI 9%, 14%) less likely to achieve expected levels at ages 11 and 16, respectively, after adjustment for socioeconomic dep...