Plant-Derived Exosome-Like Nanoparticles: Emerging Nanosystems for Enhanced Tissue Engineering

作者：Hui Feng, Yue Yang, Yan Zhang, Jingqi Liang, Liang Liu, Qiong Wang, Qian Feng, Hongmou Zhao · 发表于：International Journal of Nanomedicine · 年份：2024 · DOI：10.2147/ijn.s448905 · 被引用次数：64 · 研究领域：Extracellular vesicles in disease、RNA Interference and Gene Delivery、MicroRNA in disease regulation

Tissue engineering holds great potential for tissue repair and rejuvenation. Plant-derived exosome-like nanoparticles (ELNs) have recently emerged as a promising avenue in tissue engineering. However, there is an urgent need to understand how plant ELNs can be therapeutically applied in clinical disease management, especially for tissue regeneration. In this review, we comprehensively examine the properties, characteristics, and isolation techniques of plant ELNs. We also discuss their impact on the immune system, compatibility with the human body, and their role in tissue regeneration. To ensure the suitability of plant ELNs for tissue engineering, we explore various engineering and modification strategies. Additionally, we provide insights into the progress of commercialization and industrial perspectives on plant ELNs. This review aims to highlight the potential of plant ELNs in regenerative medicine by exploring the current research landscape and key findings.