Technical note: Generalizable and promptable artificial intelligence model to augment clinical delineation in radiation oncology

作者：Lian Zhang, Zhengliang Liu, Lu Zhang, Zihao Wu, Xiaowei Yu, Jason Holmes, Hongying Feng, Haixing Dai, Xiang Li, Quanzheng Li, William W. Wong, Sujay A. Vora, Dajiang Zhu, Tianming Liu, Wei Liu · 发表于：Medical Physics · 年份：2024 · DOI：10.1002/mp.16965 · 被引用次数：14 · 研究领域：Advanced Radiotherapy Techniques、Prostate Cancer Diagnosis and Treatment、Effects of Radiation Exposure

BACKGROUND: Efficient and accurate delineation of organs at risk (OARs) is a critical procedure for treatment planning and dose evaluation. Deep learning-based auto-segmentation of OARs has shown promising results and is increasingly being used in radiation therapy. However, existing deep learning-based auto-segmentation approaches face two challenges in clinical practice: generalizability and human-AI interaction. A generalizable and promptable auto-segmentation model, which segments OARs of multiple disease sites simultaneously and supports on-the-fly human-AI interaction, can significantly enhance the efficiency of radiation therapy treatment planning. PURPOSE: Meta's segment anything model (SAM) was proposed as a generalizable and promptable model for next-generation natural image segmentation. We further evaluated the performance of SAM in radiotherapy segmentation. METHODS: Computed tomography (CT) images of clinical cases from four disease sites at our institute were collected: prostate, lung, gastrointestinal, and head & neck. For each case, we selected the OARs important in radiotherapy treatment planning. We then compared both the Dice coefficients and Jaccard indices derived from three distinct methods: manual delineation (ground truth), automatic segmentation using SAM's 'segment anything' mode, and automatic segmentation using SAM's 'box prompt' mode that implements manual interaction via live prompts during segmentation. RESULTS: Our results indicate that SAM's ...