CD206 modulates the role of M2 macrophages in the origin of metastatic tumors

作者：Hui Li, Ying-Qi Miao, Liping Suo, Xi Wang, Yiqing Mao, Xuehui Zhang, Na Zhou, Jun-Rui Tian, Xiuyan Yu, Tong-Xia Wang, Yan Gao, Hongyan Guo, Zheng Zhang, Dian-Sheng Ma, Hongxia Wu, Yanwei Cui, Xiliang Zhang, Xiaochun Chi, Yu‐Chi Li, David M. Irwin, Gang Niu, Huanran Tan · 发表于：Journal of Cancer · 年份：2024 · DOI：10.7150/jca.91944 · 被引用次数：13 · 研究领域：Phagocytosis and Immune Regulation、Immune cells in cancer、Extracellular vesicles in disease

mouse models. In summary, we show that M2 macrophages in the blood circulation underwent a "change of loyalty" to become "cancer cells" that transformed into distal tissue metastasis, which could be suppressed by the knockdown of CD206 expression.