Polycomb repressive complex 1 modulates granulosa cell proliferation in early folliculogenesis to support female reproduction

作者：Meng Gao, Tuo Zhang, Tengxiang Chen, Ziqi Chen, Zijian Zhu, Yang Wen, Shaogang Qin, Yibing Bao, Ting Zhao, Hengxing Li, Longping Liu, Ming Hao, Jianbin Wang, Fengchao Wang, Haibin Wang, Bo Zhou, Hua Zhang, Guoliang Xia, Chao Wang · 发表于：Theranostics · 年份：2024 · DOI：10.7150/thno.89878 · 被引用次数：22 · 研究领域：Reproductive Biology and Fertility、Renal and related cancers、Epigenetics and DNA Methylation

Our findings highlighted the pivotal role of PRC1 as an epigenetic regulator of gene transcription networks in GC proliferation during early folliculogenesis. In the future, a better understanding of molecular details of PRC1 structural and functional abnormalities may contribute to POI diagnosis and therapeutic options.