Tumor cell senescence-induced macrophage CD73 expression is a critical metabolic immune checkpoint in the aging tumor microenvironment

作者：Yue Deng, Qingyan Chen, Xiao Yang, Yajie Sun, Bin Zhang, Wenwen Wei, Suke Deng, Jingshu Meng, Yan Hu, Yijun Wang, Zhanjie Zhang, Lu Wen, Fang Huang, Chao Wan, Kunyu Yang · 发表于：Theranostics · 年份：2024 · DOI：10.7150/thno.91119 · 被引用次数：51 · 研究领域：Immune cells in cancer、Nanoplatforms for cancer theranostics、Epigenetics and DNA Methylation

TAMs expressed CD73 contributes significantly to the adenosine accumulation in the senescent TME, suggesting targeting CD73 is a novel synergistic anti-tumor strategy in the aging microenvironment.