Problematic alcohol use and its impact on liver disease quality of life in a multicenter study of patients with cirrhosis

作者：Jeremy W. Luk, Derek D. Satre, Ramsey Cheung, Robert J. Wong, Alexander Monto, Jennifer Y. Chen, Steven L. Batki, Michael J. Ostacher, Hannah R. Snyder, Amy M. Shui, Meimei Liao, Christina G. Haight, Mandana Khalili · 发表于：Hepatology Communications · 年份：2024 · DOI：10.1097/hc9.0000000000000379 · 被引用次数：17 · 研究领域：Alcohol Consumption and Health Effects、Liver Disease and Transplantation、Liver Disease Diagnosis and Treatment

BACKGROUND: Management of cirrhosis is challenging and has been complicated by the COVID-19 pandemic due to decreased access to care, increased psychological distress, and alcohol misuse. Recently, The National Institute on Alcohol Abuse and Alcoholism has broadened the definition of recovery from alcohol use disorder to include quality of life (QoL) as an indicator of recovery. This study examined the associations of alcohol-associated cirrhosis etiology and problematic drinking with liver disease QoL (LDQoL). METHODS: Patients with cirrhosis (N=329) were recruited from 3 sites (63% from 2 Veterans Affairs Health Care Systems and 37% from 1 safety net hospital) serving populations that are economically or socially marginalized. Cirrhosis etiology was ascertained by chart review of medical records. Problematic drinking was defined by ≥8 on the Alcohol Use Disorders Identification Test. Multivariable general linear modeling adjusting for age, sex, race/ethnicity, site, pandemic-related stress, and history of anxiety/depressive disorder were conducted. Sensitivity analyses further adjusted for indicators of liver disease severity. RESULTS: Participants were on average 64.6 years old, 17% female, 58% non-White, 44% with alcohol-associated cirrhosis, and 17% with problematic drinking. Problematic drinking was significantly associated with worse LDQoL scores in the overall scale and in the memory/concentration and health distress subscales. These associations remained significant ...