S100b treatment overcomes RAGE signaling deficits in myoblasts on advanced glycation end-product cross-linked collagen and promotes myogenic differentiation

作者：Lucas C. Olson, Tri Nguyen, Eleanor L. Sabalewski, Jennifer L. Puetzer, Zvi Schwartz, Michael J. McClure · 发表于：American Journal of Physiology-Cell Physiology · 年份：2024 · DOI：10.1152/ajpcell.00502.2023 · 被引用次数：7 · 研究领域：Muscle Physiology and Disorders、Advanced Glycation End Products research、S100 Proteins and Annexins

Collagen cross-linked by advanced glycation end-products (AGEs) induced myoblast proliferation but prevented differentiation, myotube formation, and RAGE upregulation. RAGE inhibition occluded AGE-induced myoblast proliferation, while the delivery of S100b, a RAGE ligand, recovered fusion deficits.