Real-world observations and impacts of Chinese herbal medicine for migraine: results of a registry-based cohort study

作者：Shaohua Lyu, Claire Shuiqing Zhang, Anthony Lin Zhang, Xinfeng Guo, Rong Hua, Zhenhui Mao, Qiaozhen Su, Charlie Changli Xue, Jingbo Sun · 发表于：Frontiers in Pharmacology · 年份：2024 · DOI：10.3389/fphar.2024.1330589 · 被引用次数：8 · 研究领域：Migraine and Headache Studies、Complementary and Alternative Medicine Studies、Olfactory and Sensory Function Studies

Background: Migraine is a prevalent, recurrent condition with substantial disease burden. Chinese herbal medicine (CHM) has been used frequently for migraine in controlled clinical settings. This study is to summarise the characteristics of patients who seek clinical care in a tertiary Chinese medicine hospital in China; to gather their preferences and values of using CHM; to explore the effect of CHM for migraine and its comorbidities in a real-world setting, and to collect first-hand expertise of clinicians’ practice pattern in prescribing CHM for migraine. Methods: This registry-based cohort study was prospectively conducted at Guangdong Provincial Hospital of Chinese Medicine from December 2020 to May 2022. Adult migraine patients seeking their initial anti-migraine clinical care at the hospital were consecutively recruited and followed up for 12 weeks. Practitioners specialised in headache management prescribed individualised treatments without research interference. Standardised case report forms were employed to gather information on patients’ preferences and perspective of seeking clinical care, as well as to assess participants’ migraine severity, comorbidities, and quality of life, at 4-weeks intervals. Various analytical methods were utilised based on the computed data. Results: In this study, we observed 248 participants. Of these, 73 received CHM treatment for 28 days or longer. Notably, these participants exhibited a greater disease severity, compared to those t...