TGR5 signalling in heart and brain injuries: focus on metabolic and ischaemic mechanisms

作者：Nan‐Jie Xu, Yufeng He, Chunyu Zhang, Yongqiang Zhang, Shengjie Cheng, Li Deng, 義夫 田中, Bin Liao, Yan Wei, Jian Feng · 发表于：Neurobiology of Disease · 年份：2024 · DOI：10.1016/j.nbd.2024.106428 · 被引用次数：8 · 研究领域：Hyperglycemia and glycemic control in critically ill and hospitalized patients、Peroxisome Proliferator-Activated Receptors、Diet and metabolism studies

The heart and brain are the core organs of the circulation and central nervous system, respectively, and play an important role in maintaining normal physiological functions. Early neuronal and cardiac damage affects organ function. The relationship between the heart and brain is being continuously investigated. Evidence-based medicine has revealed the concept of the "heart- brain axis," which may provide new therapeutic strategies for certain diseases. Takeda protein-coupled receptor 5 (TGR5) is a metabolic regulator involved in energy homeostasis, bile acid homeostasis, and glucose and lipid metabolism. Inflammation is critical for the development and regeneration of the heart and brain during metabolic diseases. Herein, we discuss the role of TGR5 as a metabolic regulator of heart and brain development and injury to facilitate new therapeutic strategies for metabolic and ischemic diseases of the heart and brain.