Involvement and repair of epithelial barrier dysfunction in allergic diseases

作者：Hui-Fei Lu, Yi-Chi Zhou, Litao Yang, Qian Zhou, Xi-Jia Wang, Shuqi Qiu, Bao‐Hui Cheng, Xianhai Zeng · 发表于：Frontiers in Immunology · 年份：2024 · DOI：10.3389/fimmu.2024.1348272 · 被引用次数：52 · 研究领域：Allergic Rhinitis and Sensitization、Dermatology and Skin Diseases、Asthma and respiratory diseases

The epithelial barrier serves as a critical defense mechanism separating the human body from the external environment, fulfilling both physical and immune functions. This barrier plays a pivotal role in shielding the body from environmental risk factors such as allergens, pathogens, and pollutants. However, since the 19th century, the escalating threats posed by environmental pollution, global warming, heightened usage of industrial chemical products, and alterations in biodiversity have contributed to a noteworthy surge in allergic disease incidences. Notably, allergic diseases frequently exhibit dysfunction in the epithelial barrier. The proposed epithelial barrier hypothesis introduces a novel avenue for the prevention and treatment of allergic diseases. Despite increased attention to the role of barrier dysfunction in allergic disease development, numerous questions persist regarding the mechanisms underlying the disruption of normal barrier function. Consequently, this review aims to provide a comprehensive overview of the epithelial barrier's role in allergic diseases, encompassing influencing factors, assessment techniques, and repair methodologies. By doing so, it seeks to present innovative strategies for the prevention and treatment of allergic diseases.