3D ‐Printed Personalized Lattice Implant as an Innovative Strategy to Reconstruct Geographic Defects in Load‐Bearing Bones

作者：Zhuangzhuang Li, Minxun Lu, Yuqi Zhang, Jie Wang, Yitian Wang, Taojun Gong, Xuanhong He, Yi Luo, Yong Zhou, Li Min, Chongqi Tu · 发表于：Orthopaedic Surgery · 年份：2024 · DOI：10.1111/os.14003 · 被引用次数：12 · 研究领域：Orthopaedic implants and arthroplasty、Bone Tissue Engineering Materials、Advanced X-ray and CT Imaging

OBJECTIVE: Geographic defect reconstruction in load-bearing bones presents formidable challenges for orthopaedic surgeon. The use of 3D-printed personalized implants presents a compelling opportunity to address this issue. This study aims to design, manufacture, and evaluate 3D-printed personalized implants with irregular lattice porous structures for geographic defect reconstruction in load-bearing bones, focusing on feasibility, osseointegration, and patient outcomes. METHODS: This retrospective study involved seven patients who received 3D-printed personalized lattice implants for the reconstruction of geographic defects in load-bearing bones. Personalized implants were customized for each patient. Randomized dodecahedron unit cells were incorporated within the implants to create the porous structure. The pore size and porosity were analyzed. Patient outcomes were assessed through a combination of clinical and radiological evaluations. Tomosynthesis-Shimadzu metal artifact reduction technology (T-SMART) was utilized to evaluate osseointegration. Functional outcomes were assessed according to the Musculoskeletal Tumor Society (MSTS) 93 score. RESULTS: Multiple pore sizes were observed in porous structures of the implant, with a wide distribution range (approximately 300-900 um). The porosity analysis results showed that the average porosity of irregular porous structures was around 75.03%. The average follow-up time was 38.4 months, ranging from 25 to 50 months. Postoperati...