Awake brain mapping paradigms for nondominant hemisphere gliomas

作者：Justyna O. Ekert, David S. Sabsevitz, Isabel Martin del Campo, Anshit Goyal, Conor S. Gillespie, Erik H. Middlebrooks, Kaisorn L. Chaichana, Keng Siang Lee, Jesús E. Sánchez-Garavito, Alfredo Quiñones‐Hinojosa · 发表于：Neurosurgical FOCUS · 年份：2024 · DOI：10.3171/2023.11.focus23610 · 被引用次数：10 · 研究领域：Glioma Diagnosis and Treatment、Spatial Neglect and Hemispheric Dysfunction、Meningioma and schwannoma management

OBJECTIVE: Traditionally, resection of nondominant hemisphere brain tumors was performed under general anesthesia. An improved understanding of right-lateralized neural networks has led to a paradigm shift in recent decades, where the right or nondominant hemisphere is no longer perceived as "functionally silent." There is an increasing interest in awake brain mapping for nondominant hemisphere resections. The objective of this study was to perform a comprehensive review of the existing brain mapping paradigms for patients with nondominant hemisphere gliomas undergoing awake craniotomies. METHODS: In accordance with PRISMA guidelines, systematic searches of the Medline, Embase, and American Psychological Association PsycInfo databases were undertaken from database inception to July 1, 2023. Studies providing a description of the intraoperative mapping paradigm used to assess cognition during an awake craniotomy for resection of a nondominant hemisphere glioma were included. RESULTS: The search yielded 1084 potentially eligible articles. Thirty-nine unique studies reporting on 788 patients were included in the systematic review. The most frequently tested cognitive domains in patients with nondominant hemisphere tumors were spatial attention/neglect (17/39 studies, 43.6%), speech-motor/language (17/39 studies, 43.6%), and social cognition (9/39 studies, 23.1%). Within the frontal lobe, the highest number of positive mapping sites was identified for speech-motor/language, spati...