L-shaped association between dietary zinc intake and cognitive decline in Chinese older people

作者：Qiguo Meng, Mengyi Liu, Cheng Zu, Xinyue Su, Yuanxiu Wei, Xiaoqin Gan, Yuanyuan Zhang, Panpan He, Chun Zhou, Ziliang Ye, Chengzhang Liu, Xianhui Qin · 发表于：Age and Ageing · 年份：2024 · DOI：10.1093/ageing/afae008 · 被引用次数：9 · 研究领域：Trace Elements in Health、Heavy Metal Exposure and Toxicity、Selenium in Biological Systems

BACKGROUND AND OBJECTIVE: The prospective association between dietary zinc (Zn) intake and cognitive decline remains uncertain. We aimed to assess the relationship of dietary Zn intake with the risk of cognitive decline in the Chinese older people, and examine the possible effect modifiers on this association. METHODS: A total of 3,106 older Chinese adults aged 55 years or older from China Health and Nutrition Survey were included. Dietary nutrients intake information was collected by combined 24-h dietary recalls with weighing food inventory. The cognitive decline was defined as the 5-year decline rate in global and composite cognitive scores, based on a subset of items from the Telephone Interview for Cognitive Status-modified. RESULTS: The median follow-up duration was 5.9 years. There was an L-shaped association between dietary Zn intake and the 5-year decline rates in global and composite cognitive scores, with an inflection point at 8.8 mg/day of dietary Zn. For the composite cognitive scores, compared with the first quantile (<7.9 mg/day) of dietary Zn intake, quantiles 2-6 (≥7.9 mg/day) had a significantly slower cognitive decline rate (β: -0.24; 95% confidence interval: -0.40 to -0.07). Similar results were found for the global cognitive scores. Moreover, the inverse association between dietary Zn intake and cognitive decline in composite cognitive scores was significantly stronger in those with lower levels of physical activity (P-interactions = 0.041). CONCLUSION: ...