Impact of preconception and antenatal supplementation with myo-inositol, probiotics, and micronutrients on offspring BMI and weight gain over the first 2 years

作者：Jaz Lyons‐Reid, José G. B. Derraik, Timothy Kenealy, Benjamin B. Albert, J. Manuel Ramos Nieves, Cathríona R. Monnard, Philip Titcombe, Heidi Nield, Sheila J. Barton, Sarah El‐Heis, Elizabeth Huiwen Tham, Keith M. Godfrey, Shiao‐Yng Chan, Wayne S. Cutfield, NiPPeR Study Group, Ryan Carvalho, Julie Ann Guiao Castro, Mary Cavanagh, Hsin‐Fang Chang, Yap Seng Chong, Paula Costello, Vanessa Cox, Sevasti Galani, Judith Hammond, Nicholas C. Harvey, Soo Min Han, Mrunalini Jagtap, Chiara Nembrini, Justin M. O’Sullivan, Judith Ong, Irma Silva‐Zolezzi, Wendy Sim, Vicky Tay, Mya Thway Tint, Mark H. Vickers, Jui‐Tsung Wong, Gladys Woon, Wen Lun Yuan · 发表于：BMC Medicine · 年份：2024 · DOI：10.1186/s12916-024-03246-w · 被引用次数：9 · 研究领域：Gestational Diabetes Research and Management、Birth, Development, and Health、Pregnancy and preeclampsia studies

BACKGROUND: Nutritional intervention preconception and throughout pregnancy has been proposed as an approach to promoting healthy postnatal weight gain in the offspring but few randomised trials have examined this. METHODS: Measurements of weight and length were obtained at multiple time points from birth to 2 years among 576 offspring of women randomised to receive preconception and antenatally either a supplement containing myo-inositol, probiotics, and additional micronutrients (intervention) or a standard micronutrient supplement (control). We examined the influence on age- and sex-standardised BMI at 2 years (WHO standards, adjusting for study site, sex, maternal parity, smoking and pre-pregnancy BMI, and gestational age), together with the change in weight, length, BMI from birth, and weight gain trajectories using latent class growth analysis. RESULTS: At 2 years, there was a trend towards lower mean BMI among intervention offspring (adjusted mean difference [aMD] - 0.14 SD [95% CI 0.30, 0.02], p = 0.09), and fewer had a BMI > 95th percentile (i.e. > 1.65 SD, 9.2% vs 18.0%, adjusted risk ratio [aRR] 0.51 [95% CI 0.31, 0.82], p = 0.006). Longitudinal data revealed that intervention offspring had a 24% reduced risk of experiencing rapid weight gain > 0.67 SD in the first year of life (21.9% vs 31.1%, aRR 0.76 [95% CI 0.58, 1.00], p = 0.047). The risk was likewise decreased for sustained weight gain > 1.34 SD in the first 2 years of life (7.7% vs 17.1%, aRR 0.55 [95% CI 0...