Discovery and heterologous biosynthesis of glycosylated polyketide luteodienoside A reveals unprecedented glucinol-mediated product offloading by a fungal carnitine O -acyltransferase domain

作者：Amr A. Arishi, Zhuo Shang, Ernest Lacey, Andrew Crombie, Daniel Vuong, Hang Li, Joe Bracegirdle, Peter Turner, William Lewis, Gavin R. Flematti, Andrew M. Piggott, Yit‐Heng Chooi · 发表于：Chemical Science · 年份：2024 · DOI：10.1039/d3sc05008d · 被引用次数：15 · 研究领域：Microbial Natural Products and Biosynthesis、Carbohydrate Chemistry and Synthesis、Fungal and yeast genetics research

-dimethylation of the 3-hydroxy-2,2,4-trimethylocta-4,6-dienoic acid intermediate, without requiring reversible product release and recapture by the cAT domain. This study expands the repertoire of polyketide modifications known to be catalysed by cAT domains and highlights the potential of mining fungal genomes for this subclass of fungal PKSs to discover new structurally diverse secondary metabolites.