Risk factors of neuropathic pain in multiple sclerosis: a retrospective case-cohort study

作者：Huiying Ouyang, Xiaojun Li, Haoyou Xu, Yibo Zhan, Zequan Zheng, Guixian Chen, Zhenzhen Lou, Haoxuan Chen, Jiahui Zhang, Hui Mao, Changlin Zhang, Lulu Qin, Yuanqi Zhao, Min Zhao · 发表于：Frontiers in Immunology · 年份：2024 · DOI：10.3389/fimmu.2024.1309583 · 被引用次数：8 · 研究领域：Pain Mechanisms and Treatments、Multiple Sclerosis Research Studies、Peripheral Neuropathies and Disorders

Background: Pain is a common symptom in multiple sclerosis (MS), especially neuropathic pain, which has a significant impact on patients' mental and physical health and quality of life. However, risk factors that related to neuropathic pain, still remain unclear. Objective: The study aimed to explore the risk factors of neuropathic pain among MS patients. Materials and methods: This retrospective study examined the consecutive patients diagnosed with MS in the Department of Neurology of Guangdong Provincial Hospital of Chinese Medicine between August 2011 and October 2022. Neuropathic pain was defined as "pain arising as a direct consequence of a lesion or disease affecting the somatosensory system". Demographic and clinical features were obtained from the electronic system of the hospital. Results: Our cohort revealed that the prevalence of patients with neuropathic pain in MS was 34.1%. The results indicated that the longer the spinal lesions, the greater the neuropathic pain risks (2-4: OR, 13.3(2.1-82), >5: OR, 15.2(2.7-86.8), p for tread: 0.037). Meanwhile, multivariate regression analysis showed that cervical and thoracic lesions (OR 4.276, 95% CI 1.366-13.382, P = 0.013), upper thoracic lesions (T1-T6) (OR 3.047, 95% CI 1.018-9.124, P = 0.046) were positively correlated with neuropathic pain, while basal ganglia lesions (OR 0.188, 95% CI 0.044-0.809, P = 0.025) were negatively correlated with neuropathic pain among MS patients. Conclusion: Extended spinal lesions (≥3 s...