Radiation-induced glymphatic dysfunction in patients with nasopharyngeal carcinoma: a study using diffusion tensor image analysis along the perivascular space

作者：Xingyou Zheng, Jianchun Peng, Qing Zhao, Li Li, Jianming Gao, Keyang Zhou, Bei Tan, Lingling Deng, Youming Zhang · 发表于：Frontiers in Neuroscience · 年份：2024 · DOI：10.3389/fnins.2023.1321365 · 被引用次数：7 · 研究领域：Cerebrospinal fluid and hydrocephalus、Spinal Dysraphism and Malformations、Traumatic Brain Injury and Neurovascular Disturbances

Radiation encephalopathy (RE) refers to radiation-induced brain necrosis and is a life-threatening complication in patients with nasopharyngeal carcinoma (NPC) after radiotherapy (RT), and radiation-induced pre-symptomatic glymphatic alterations have not yet been investigated. We used diffusion tensor image analysis along the perivascular space (DTI-ALPS) index to examine the pre-symptomatic glymphatic alterations in NPC patients following RT. A total of 109 patients with NPC consisted of Pre-RT ( n = 35) and Post-RT ( n = 74) cohorts were included. The post-RT NPC patients, with normal-appearing brain structure at the time of MRI, were further divided into Post-RT-RE- ( n = 58) and Post-RT-RE+ ( n = 16) subgroups based on the detection of RE in follow-up. We observed lower DTI-ALPS left index, DTI-ALPS right index and DTI-ALPS whole brain index in post-RT patients than that in pre-RT patients ( p < 0.05). We further found that post-RT-RE+ patients demonstrated significantly lower DTI-ALPS right ( p = 0.013), DTI-ALPS whole brain ( p = 0.011) and marginally lower DTI-ALPS left ( p = 0.07) than Post-RT non-RE patients. Significant negative correlations were observed between the maximum dosage of radiation-treatment (MDRT) and DTI-ALPS left index ( p = 0.003) as well as DTI-ALPS whole brain index ( p = 0.004). Receiver operating characteristic (ROC) curve analysis showed that DTI-ALPS whole brain index exhibited good performance (AUC = 0.706) in identifying patients more...