Advances of radiolabeled GRPR ligands for PET/CT imaging of cancers

作者：Yuze Ma, Feng Gao · 发表于：Cancer Imaging · 年份：2024 · DOI：10.1186/s40644-024-00658-y · 被引用次数：25 · 研究领域：Neuropeptides and Animal Physiology、Radiopharmaceutical Chemistry and Applications、Receptor Mechanisms and Signaling

GRPR is a type of seven-transmembrane G-protein coupled receptor that belongs to the bombesin protein receptor family. It is highly expressed in various cancers, including prostate cancer, breast cancer, lung cancer, gastrointestinal cancer, and so on. As a result, molecular imaging studies have been conducted using radiolabeled GRPR ligands for tumor diagnosis, as well as monitoring of recurrence and metastasis. In this paper, we provided a comprehensive overview of relevant literature from the past two decades, with a specific focus on the advancements made in radiolabeled GRPR ligands for imaging prostate cancer and breast cancer.