Cooperative Cu/Pd-Catalyzed 1,5-Boroacylation of Cyclopropyl-Substituted Alkylidenecyclopropanes

作者：Hui-Hui Zeng, Yuqing Wang, Yong-Yu He, Xiaoling Zhong, Hongguang Li, Ai‐Jun Ma, Jin‐Bao Peng · 发表于：The Journal of Organic Chemistry · 年份：2024 · DOI：10.1021/acs.joc.3c02670 · 被引用次数：12 · 研究领域：Cyclopropane Reaction Mechanisms、Catalytic C–H Functionalization Methods、Organoboron and organosilicon chemistry

A Cu/Pd-cocatalyzed 1,5-boroacylation of cyclopropyl-substituted ACPs with B 2 pin 2 and acid chlorides has been developed. Using cyclopropyl-substituted ACPs as the starting material, a broad range of 1,5-boroacylated products with multiple functional groups was prepared in good yields with excellent regio- and stereoselectively. Both aromatic and aliphatic acid chlorides were tolerated in this reaction.