Brief webcam test of hand movements predicts episodic memory, executive function, and working memory in a community sample of cognitively asymptomatic older adults

作者：Renjie Li, Xinyi Wang, Katherine Lawler, Saurabh K. Garg†, Rebecca J. St George, Aidan Bindoff, Larissa Bartlett, Eddy Roccati, Anna E. King, James C. Vickers, Quan Bai, Jane Alty · 发表于：Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · 年份：2024 · DOI：10.1002/dad2.12520 · 被引用次数：7 · 研究领域：Dementia and Cognitive Impairment Research、Traumatic Brain Injury Research、Cancer-related cognitive impairment studies

INTRODUCTION: Low-cost simple tests for preclinical Alzheimer's disease are a research priority. We evaluated whether remote unsupervised webcam recordings of finger-tapping were associated with cognitive performance in older adults. METHODS: A total of 404 cognitively-asymptomatic participants (64.6 [6.77] years; 70.8% female) completed 10-second finger-tapping tests (Tasmanian [TAS] Test) and cognitive tests (Cambridge Neuropsychological Test Automated Battery [CANTAB]) online at home. Regression models including hand movement features were compared with null models (comprising age, sex, and education level); change in Akaike Information Criterion greater than 2 (ΔAIC > 2) denoted statistical difference. RESULTS: Hand movement features improved prediction of episodic memory, executive function, and working memory scores (ΔAIC > 2). Dominant hand features outperformed nondominant hand features for episodic memory (ΔAIC = 2.5), executive function (ΔAIC = 4.8), and working memory (ΔAIC = 2.2). DISCUSSION: This brief webcam test improved prediction of cognitive performance compared to age, sex, and education. Finger-tapping holds potential as a remote language-agnostic screening tool to stratify community cohorts at risk for cognitive decline.