Association between serum uric acid levels and lung function in the NHANES cohort (2007–2012): A cross‐sectional analysis of a diverse American population

作者：Tianlun Kang, Yajing Xi, Siyi Lu, Tangliang Qian, Mengmeng Du, Xiaojun Shi, Xiujuan Hou · 发表于：International Journal of Rheumatic Diseases · 年份：2024 · DOI：10.1111/1756-185x.15043 · 被引用次数：4 · 研究领域：Gout, Hyperuricemia, Uric Acid、Thyroid Disorders and Treatments、Diet, Metabolism, and Disease

BACKGROUND: Hyperuricemia has been linked to various health conditions. However, the relationship between uric acid (UA) levels and lung function remains debated. METHODS: In a cross-sectional study of 6750 participants aged 20-69 from NHANES, we assessed UA levels and lung function (FVC and FEV1). We conducted regression analyses while adjusting for potential confounders. RESULTS: After accounting for factors like age, sex, BMI, smoking, and more, we found a negative association between UA FVC and FEV1. Specifically, for every 0.1 mg/dL increase in UA, FEV1 decreased by 15.265 mL, and FVC decreased by 24.46 mL. No association was observed with FEV1/FVC. Subgroup analyses revealed similar negative correlations among various groups, particularly in non-Hispanic Black females under 60. CONCLUSION: Serum UA levels are inversely associated with FEV1 and FVC in the American population, with a notable impact on non-Hispanic Black females under 60.