Changes in frailty and depressive symptoms among middle-aged and older Chinese people: a nationwide cohort study

作者：Ni Sang, Rong-chao Liu, Minghui Zhang, Zong-Xiao Lu, Zhen-Gang Wu, Mengyao Zhang, Bohan Li, Meng Wei, Hai‐Feng Pan, Guo‐Cui Wu · 发表于：BMC Public Health · 年份：2024 · DOI：10.1186/s12889-024-17824-3 · 被引用次数：32 · 研究领域：Frailty in Older Adults、Chronic Disease Management Strategies、Aging and Gerontology Research

BACKGROUND AND AIMS: The older people bears a severe burden of disease due to frailty and depressive symptoms, however, the results of association between the two in the older Chinese people have been conflicting. Therefore, this study aimed to investigate the developmental trajectories and interactions of frailty and depressive symptoms in the Chinese middle-aged and older adults. METHODS: The study used four waves of data from 2011, 2013, 2015 and 2018 in the China Health and Retirement Longitudinal Study (CHARLS) database, focused on middle-aged and older people ≥ 45 years of age, and analyzed using latent growth models and cross-lagged models. RESULTS: The parallel latent growth model showed that the initial level of depressive symptoms had a significant positive predictive effect on the initial level of frailty. The rate of change in depressive symptoms significantly positively predicted the rate of change in frailty. The initial level of frailty had a significant positive predictive effect on the initial level of depressive symptoms, but a significant negative predictive effect on the rate of change in depressive symptoms. The rate of change in frailty had a significant positive predictive effect on the rate of change in depressive symptoms. The results of the cross-lagged analysis indicated a bidirectional causal association between frailty and depressive symptoms in the total sample population. Results for the total sample population grouped by age and gender were con...