PD ‐1: A critical player and target for immune normalization

作者：Xuening Liu, Alison Zhao, Su Xiao, Haohao Li, Meng-Hua Li, Wei Guo, Qiuju Han · 发表于：Immunology · 年份：2024 · DOI：10.1111/imm.13755 · 被引用次数：18 · 研究领域：Cancer Immunotherapy and Biomarkers、CAR-T cell therapy research、Immune Cell Function and Interaction

Immune system imbalances contribute to the pathogenesis of several different diseases, and immunotherapy shows great therapeutic efficacy against tumours and infectious diseases with immune-mediated derivations. In recent years, molecules targeting the programmed cell death protein 1 (PD-1) immune checkpoint have attracted much attention, and related signalling pathways have been studied clearly. At present, several inhibitors and antibodies targeting PD-1 have been utilized as anti-tumour therapies. However, increasing evidence indicates that PD-1 blockade also has different degrees of adverse side effects, and these new explorations into the therapeutic safety of PD-1 inhibitors contribute to the emerging concept that immune normalization, rather than immune enhancement, is the ultimate goal of disease treatment. In this review, we summarize recent advancements in PD-1 research with regard to immune normalization and targeted therapy.