Cytisine: State of the art in pharmacological activities and pharmacokinetics

作者：Xuezhen Wang, Jiaming Yang, Peifeng Huang, Dong Wang, Zhibin Zhang, Zehua Zhou, Leiqin Liang, Rongmei Yao, Yang Long · 发表于：Biomedicine & Pharmacotherapy · 年份：2024 · DOI：10.1016/j.biopha.2024.116210 · 被引用次数：19 · 研究领域：Nicotinic Acetylcholine Receptors Study、Synthesis and Biological Evaluation、Chemical synthesis and alkaloids

Cytisine is a naturally occurring bioactive compound, an alkaloid mainly isolated from legume plants. In recent years, various biological activities of cytisine have been explored, showing certain effects in smoking cessation, reducing drinking behavior, anti-tumor, cardiovascular protection, blood sugar regulation, neuroprotection, osteoporosis prevention and treatment, etc. At the same time, cytisine has the advantages of high efficiency, safety, and low cost, has broad development prospects, and is a drug of great application value. However, a summary of cytisine's biological activities is currently lacking. Therefore, this paper summarizes the pharmacological action, mechanism, and pharmacokinetics of cytisine by referring to numerous databases, and analyzes the new and core targets of cytisine with the help of computer simulation technology, to provide reference for doctors.