Hypometabolic patterns are related to post‐surgical seizure outcomes in focal cortical dysplasia: A semi‐quantitative study

作者：Yuan Yao, Xiu Wang, Baotian Zhao, Jiajie Mo, Zhihao Guo, Bowen Yang, Zilin Li, Xiuliang Fan, Du Cai, Lin Sang, Zhong Zheng, Xiaoqiu Shao, Lin Ai, Wenhan Hu, Chao Zhang, Kai Zhang · 发表于：Epilepsia Open · 年份：2024 · DOI：10.1002/epi4.12903 · 被引用次数：12 · 研究领域：Epilepsy research and treatment、Glioma Diagnosis and Treatment、Pharmacological Effects and Toxicity Studies

OBJECTIVE: Fluorine-18-fluorodeoxyglucose-positron emission tomography (FDG-PET) is routinely used for presurgical evaluation in many epilepsy centers. Hypometabolic characteristics have been extensively examined in prior studies, but the metabolic patterns associated with specific pathological types of drug-resistant epilepsy remain to be fully defined. This study was developed to explore the relationship between metabolic patterns or characteristics and surgical outcomes in type I and II focal cortical dysplasia (FCD) patients based on results from a large cohort. METHODS: Data from individuals who underwent epilepsy surgery from 2014 to 2019 with a follow-up duration of over 3 years and a pathological classification of type I or II FCD in our hospital were retrospectively analyzed. Hypometabolic patterns were quantitatively identified via statistical parametric mapping (SPM) and qualitatively analyzed via visual examination of PET-MRI co-registration images. Univariate analyses were used to explore the relationship between metabolic patterns and surgical outcomes. RESULTS: In total, this study included data from 210 patients. Following SPM calculations, four hypometabolic patterns were defined including unilobar, multi-lobar, and remote patterns as well as cases where no pattern was evident. In type II FCD patients, the unilobar pattern was associated with the best surgical outcomes (p = 0.014). In visual analysis, single gyrus (p = 0.032) and Clear-cut hypometabolism edge...