A Gender-, Age-, and Weight Status-Specific Analysis of the High Prevalence of Hyperuricemia Among Chinese Children and Adolescents with Obesity

作者：Meijuan Liu, Bingyan Cao, Qipeng Luo, Yanning Song, Yuting Shi, Ming Yu Cheng, Kai Liu, Di Mao, Xinmeng Wang, Chunxiu Gong · 发表于：Diabetes Metabolic Syndrome and Obesity · 年份：2024 · DOI：10.2147/dmso.s448638 · 被引用次数：19 · 研究领域：Gout, Hyperuricemia, Uric Acid、Thyroid Disorders and Treatments、Diet, Metabolism, and Disease

Objective: To explore the gender-, age-, and weight status-specific prevalence of hyperuricemia (HUA) and its associated risk factors among Chinese children and adolescents with obesity. Methods: A total of 1329 children aged 2– 17 years, who were diagnosed with obesity and hospitalized in our center from January 2016 to December 2022 were recruited. They were divided into mild obesity, moderate obesity, and severe obesity groups. HUA was defined as fasting serum uric acid level > 420 μmol/L for boys and > 360 μmol/L for girls. Multivariate logistic regression analyses were performed to identify risk factors for HUA. Results: The highest proportion of hospitalized obese children was aged 10– 13 years comprising 677 (50.9%) followed by those aged 6– 9 years comprising 348 (26.2%) whereas the least proportion was aged 2– 5 years comprising 76 (5.7%). The above differences in age distribution were still present in subgroup analyses according to weight status. Most hospitalized obese children were boys (64.7%), especially in the severe obesity group (75.0%). The overall estimated prevalence of HUA in obese children was 54.8%. It presented a gradual increase trend over the last 7 years, with more rapidly in boys than in girls. Subgroup analysis by weight status showed that the prevalence of HUA was higher in children with moderate obesity (64.3%) and severe obesity (64.2%) when compared with mild obesity (48.2%) ( P all< 0.01). Boys reached a relatively high HUA incidence level (≥...