In vitro susceptibility of nontuberculous mycobacteria in China

作者：Weicong Ren, Yaoju Tan, Zichun Ma, Yuanyuan Shang, Shanshan Li, Xuxia Zhang, Wei Wang, Cong Yao, Jinfeng Yuan, Liang Li, Yu Pang · 发表于：BMC Infectious Diseases · 年份：2024 · DOI：10.1186/s12879-024-09016-6 · 被引用次数：6 · 研究领域：Mycobacterium research and diagnosis、Tuberculosis Research and Epidemiology、Diagnosis and treatment of tuberculosis

OBJECTIVES: This study aimed to measure the prevalence of resistance to antimicrobial agents, and explore the risk factors associated with drug resistance by using nontuberculous Mycobacteria (NTM) isolates from China. METHODS: A total of 335 NTM isolates were included in our analysis. Broth dilution method was used to determine in vitro drug susceptibility of NTM isolates. RESULTS: of 8 and 64 mg/L, respectively. 51% of 244 MI isolates exhibited resistance to amikacin (AMK). For 91 Mycobacterium abscessus complex (MABC) isolates, 6 (7%) and 49 (54%) isolates were categorized as resistant to CLA at day 3 and 14, respectively. The resistance rate to CLA for Mycobacterium abscessus subspecies abscessus (MAA) was dramatically higher than that for Mycobacterium abscessus subspecies massiliense (MAM). Additionally, the percentage of patients presenting fever in the CLA-susceptible group was significantly higher than that in the CLA-resistant group. CONCLUSIONS: Our data demonstrate that approximate one fifth of MI isolates are resistant to CLA. We have identified a higher proportion of CLA-resistant MAA isolates than MAM. The patients caused by CLA-resistant MI are at low risk for presenting with fever relative to CLA-susceptible group.