Association between type 2 diabetes mellitus and body composition based on MRI fat fraction mapping

作者：Qi An, Qinhe Zhang, Yue Wang, Han‐Yue Zhang, Yuhui Liu, Ziting Zhang, Meiling Zhang, Liangjie Lin, Hui He, Yifan Yang, Peng Sun, Zhenyu Zhou, Qingwei Song, Ailian Liu · 发表于：Frontiers in Public Health · 年份：2024 · DOI：10.3389/fpubh.2024.1332346 · 被引用次数：18 · 研究领域：Nutrition and Health in Aging、Diabetes, Cardiovascular Risks, and Lipoproteins、Body Composition Measurement Techniques

Purpose To explore the association between type 2 diabetes mellitus (T2DM) and body composition based on magnetic resonance fat fraction (FF) mapping. Methods A total of 341 subjects, who underwent abdominal MRI examination with FF mapping were enrolled in this study, including 68 T2DM patients and 273 non-T2DM patients. The FFs and areas of visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT) and abdominal muscle (AM) were measured at the level of the L1-L2 vertebral. The FF of bone marrow adipose tissue (BMAT) was determined by the averaged FF values measured at the level of T12 and L1 vertebral, respectively. The whole hepatic fat fraction (HFF) and pancreatic fat fraction (PFF) were measured based on 3D semi-automatic segmentation on the FF mapping. All data were analyzed by GraphPad Prism and MedCalc. Results VAT area, VAT FF, HFF, PFF of T2DM group were higher than those of non-T2DM group after adjusting for age and sex ( P < 0.05). However, there was no differences in SAT area, SAT FF, BMAT FF, AM area and AM FF between the two groups ( P > 0.05). VAT area and PFF were independent risk factors of T2DM (all P < 0.05). The area under the curve (AUC) of the receiver operating characteristic (ROC) for VAT area and PFF in differentiating between T2DM and non-T2DM were 0.685 and 0.787, respectively, and the AUC of PFF was higher than VAT area ( P < 0.05). Additionally, in seemingly healthy individuals, the SAT area, VAT area, and AM ar...