Implementation of micelle-enabled C(sp 2 )–C(sp 3 ) cross-electrophile coupling in pharmaceutical synthesis

作者：Bin Wu, Ning Ye, Kangming Zhao, Min Shi, Jia‐Yu Liao, Jing Zhang, Wei Chen, Xianzhong Li, Yufeng Han, Margery Cortes‐Clerget, Morgan Regnier, Michaël Parmentier, Christian Mathes, Florian A. Rampf, Fabrice Gallou · 发表于：Chemical Communications · 年份：2024 · DOI：10.1039/d3cc05916b · 被引用次数：11 · 研究领域：Catalytic Cross-Coupling Reactions、Catalytic C–H Functionalization Methods、Cyclopropane Reaction Mechanisms

A sustainable C(sp 2 )–C(sp 3 ) cross-electrophile coupling was developed between readily available 5-bromophthalide and 1-benzyl-4-iodopiperidine under micellar conditions, leading to a key intermediate of one of our development compounds.