Enhanced C‐To‐T and A‐To‐G Base Editing in Mitochondrial DNA with Engineered DdCBE and TALED (Adv. Sci. 3/2024)

作者：Yinghui Wei, Ming Jin, Shuhong Huang, Fangyao Yao, Ningxin Ren, Kun Xu, Shangpu Li, Pengfei Gao, Yingsi Zhou, Yulin Chen, Hui Yang, Li Wen, Chunlong Xu, Meiling Zhang, Xiaolong Wang · 发表于：Advanced Science · 年份：2024 · DOI：10.1002/advs.202470018 · 被引用次数：1 · 研究领域：Molecular Biology Techniques and Applications、Metabolism and Genetic Disorders

Mitochondrial DNA Base Editing In article number 2304113, Yinghui Wei and co-workers successfully improve the targeting scope, efficiency, and specificity of mitochondrial DNA base editing by fusing a single-stranded deaminase (xAID) and the nuclear export signal sequence. This study offers a useful tool with broad applicability for therapy in mitochondrial genetic diseases.