Synthesis of 2-amino-9 H -chromeno[2,3- d ]thiazol-9-ones with anti-inflammatory activity via cascade reactions of 2-amino-3 iodochromones with amines and carbon disulfide

作者：Jiangtao Tan, Yifan He, Yu Lin, Yuanchen Zhong, Shijun He, Jianping Zuo, Chunhao Yang · 发表于：RSC Advances · 年份：2024 · DOI：10.1039/d3ra07209f · 被引用次数：8 · 研究领域：Synthesis of Organic Compounds、Synthesis of heterocyclic compounds、Multicomponent Synthesis of Heterocycles

copper-promoted cascade reactions was developed. The reaction employed easily available 2-amino-3-iodochromones and amines as substrates and the targeting tricyclic compounds could be obtained with moderate to good yields. Even more important, several synthesized compounds exhibited potent anti-inflammatory activities, which suggested that this protocol may provide valuable hits for drug development in the future.