Advances of research on mechanisms of acupuncture underlying improvement of ischemic stroke by regulating neuronal mitochondria.

作者：Yuxuan Li, Run-Chen Zhang, Aixin Cheng, Qing-Tao Ma, T.F. Fu, Guan-Ran Wang, Zhifang Xu, Yang Guo · 发表于：PubMed · 年份：2024 · DOI：10.13702/j.1000-0607.20220909 · 被引用次数：3 · 研究领域：Neurological Disease Mechanisms and Treatments、Acupuncture Treatment Research Studies、Healthcare and Venom Research

Acupuncture has a positive effect in the treatment of ischemic stroke (IS). A number of studies have confirmed that the role of acupuncture in the treatment of IS, which is closely related to its functions of regulating mitochondrial functions. In the present article, we review the mechanisms of acupuncture underlying improvement of mitochondria in the treatment of IS from 4 aspects： 1) protecting mitochondrial structure integrity, 2) regulative effect on mitochondrial functional activities, including regulating energy metabolism, reducing oxidative stress, suppressing calcium overload, and regulating mitochondrial membrane potential changes, 3) regulating mitochondrial quality control system, including promoting mitochondrial biosynthesis, regulating mitochondrial dynamics and apoptosis, and 4) regula-ting mitochondria-related apoptosis pathways. All of these may provide a theoretical basis for acupuncture in the treatment of IS and a reference for further research.