Regulating Androgen Receptor Function in Prostate Cancer: Exploring the Diversity of Post-Translational Modifications

作者：Lance Edward V. Lumahan, Mazia Arif, Amy E. Whitener, Ping Yi · 发表于：Cells · 年份：2024 · DOI：10.3390/cells13020191 · 被引用次数：12 · 研究领域：Prostate Cancer Treatment and Research、Estrogen and related hormone effects、Ubiquitin and proteasome pathways

Androgen receptor (AR) transcriptional activity significantly influences prostate cancer (PCa) progression. In addition to ligand stimulation, AR transcriptional activity is also influenced by a variety of post-translational modifications (PTMs). A number of oncogenes and tumor suppressors have been observed leveraging PTMs to influence AR activity. Subjectively targeting these post-translational modifiers based on their impact on PCa cell proliferation is a rapidly developing area of research. This review elucidates the modifiers, contextualizes the effects of these PTMs on AR activity, and connects these cellular interactions to the progression of PCa.