Visible-Light-Driven Multicomponent Diamination and Oxyamination of Alkene

作者：Mengping He, Chengcheng Shi, Mengqi Luo, Chao Yang, Lin Guo, Yating Zhao, Wujiong Xia · 发表于：The Journal of Organic Chemistry · 年份：2024 · DOI：10.1021/acs.joc.3c02690 · 被引用次数：14 · 研究领域：Radical Photochemical Reactions、Catalytic C–H Functionalization Methods、Sulfur-Based Synthesis Techniques

Herein, we describe an effective method for the synthesis of 2-alkoxyamides and 1,2-diamines through visible-light-mediated difunctionalization of alkenes. N -Aminopyridinium salts were employed as appropriate precursors to generate key amidyl radical intermediates via a photoinduced single-electron transfer (SET) process. The amidyl radicals would react with alkenes, followed by oxidation and nucleophilic addition. Excellent functional group tolerance and good yields demonstrate the synthetic potential of this transformation.