Pregnancy outcomes after frozen‐thawed embryo transfer in women with COVID‐19 history: A prospective cohort study

作者：Jialyu Huang, Yuxin Liu, Jiawei Wang, Dingfei Xu, Zhihui Huang, Mengxi Li, Lingling Huang, Lu Fan, Peipei Liu, Qiqi Xie, Zengming Li, Qiongfang Wu, Jiaying Lin, Leizhen Xia, Lifeng Tian · 发表于：Journal of Medical Virology · 年份：2024 · DOI：10.1002/jmv.29377 · 被引用次数：5 · 研究领域：COVID-19 Impact on Reproduction、Reproductive System and Pregnancy、Ectopic Pregnancy Diagnosis and Management

The clinical effect of Coronavirus disease 2019 (COVID-19) on endometrial receptivity and embryo implantation remains unclear. Herein, we aim to investigate whether a COVID-19 history adversely affect female pregnancy outcomes after frozen-thawed embryo transfer (FET). This prospective cohort study enrolled 230 women who underwent FET cycles from December 2022 to April 2023 in an academic fertility center. Based on the history of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection before FET, women were divided into the infected group (n = 136) and the control group (n = 94). The primary outcome was the clinical pregnancy rate per cycle. Multivariate logistic regression analysis was conducted to adjust for potential confounders, while subgroup analysis and restricted cubic splines were used to depict the effect of postinfection time interval on FET. The results showed that the clinical pregnancy rate was 59.6% in the infected group and 63.9% in the control group (p = 0.513). Similarly, the two groups were comparable in the rates of biochemical pregnancy (69.1% vs. 76.6%; p = 0.214) and embryo implantation (51.7% vs. 54.5%; p = 0.628). After adjustment, the nonsignificant association remained between prior infection and clinical pregnancy (OR = 0.78, 95% CI: 0.42-1.46). However, the odds for clinical pregnancy were significantly lower in the ≤30 days subgroup (OR = 0.15, 95% CI: 0.03-0.77), while no statistical significance was detected for 31-60 days and >6...