Motor patterns of patients with spinal muscular atrophy suggestive of sensory and corticospinal contributions to the development of locomotor muscle synergies

作者：Vincent C. K. Cheung, Sophia C. W. Ha, Janet H. Zhang, Zoe Y. S. Chan, Yanling Teng, Geshi Yeung, Lingqian Wu, Desheng Liang, Roy T.H. Cheung · 发表于：Journal of Neurophysiology · 年份：2024 · DOI：10.1152/jn.00513.2022 · 被引用次数：7 · 研究领域：Neurogenetic and Muscular Disorders Research、Robotic Locomotion and Control、Congenital heart defects research

This is likely the first report of locomotor muscle synergies of children with spinal muscular atrophy (SMA), a subject group with atypical developmental sensorimotor experience. We found that the earlier the SMA onset age, the more the subjects' synergies deviated from those of age-matched controls. This result suggests contributions of the sensory/corticospinal activities to the typical expression of locomotor modules, and how their disruptions during a critical period of development may lead to abnormal motor modules.