The Role of Diet in Parkinson’s Disease

作者：Kira Tosefsky, Julie Zhu, Yolanda N. Wang, Joyce S. T. Lam, Amanda Cammalleri, Silke Appel‐Cresswell · 发表于：Journal of Parkinson s Disease · 年份：2024 · DOI：10.3233/jpd-230264 · 被引用次数：38 · 研究领域：Parkinson's Disease Mechanisms and Treatments、Neurological diseases and metabolism、Dysphagia Assessment and Management

The aim of this review is to examine the intersection of Parkinson's disease (PD) with nutrition, to identify best nutritional practices based on current evidence, and to identify gaps in the evidence and suggest future directions. Epidemiological work has linked various dietary patterns and food groups to changes in PD risk; however, fewer studies have evaluated the role of various diets, dietary components, and supplements in the management of established PD. There is substantial interest in exploring the role of diet-related interventions in both symptomatic management and potential disease modification. In this paper, we evaluate the utility of several dietary patterns, including the Mediterranean (MeDi), Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND), Alternative Healthy Eating Index (AHEI), vegan/vegetarian, and ketogenic diet in persons with PD. Additionally, we provide an overview of the evidence relating several individual food groups and nutritional supplements to PD risk, symptoms and progression.