Self-assembly of peptide nanomaterials at biointerfaces: molecular design and biomedical applications

作者：Xin-Yuan Guo, Li Yi, Jia Yang, Hong‐Wei An, Zixin Yang, Hao Wang · 发表于：Chemical Communications · 年份：2024 · DOI：10.1039/d3cc05811e · 被引用次数：27 · 研究领域：Supramolecular Self-Assembly in Materials、Chemical Synthesis and Analysis、Advanced biosensing and bioanalysis techniques

Self-assembly is an important strategy for constructing ordered structures and complex functions in nature. Based on this, people can imitate nature and artificially construct functional materials with novel structures through the supermolecular self-assembly pathway of biological interfaces. Among the many assembly units, peptide molecular self-assembly has received widespread attention in recent years. In this review, we introduce the interactions (hydrophobic interaction, hydrogen bond, and electrostatic interaction) between peptide nanomaterials and biological interfaces, summarizing the latest advancements in multifunctional self-assembling peptide materials. We systematically demonstrate the assembly mechanisms of peptides at biological interfaces, such as proteins and cell membranes, while highlighting their application potential and challenges in fields like drug delivery, antibacterial strategies, and cancer therapy.