Regulation of ciliary homeostasis by intraflagellar transport-independent kinesins

作者：Lin Li, Jie Ran · 发表于：Cell Death and Disease · 年份：2024 · DOI：10.1038/s41419-024-06428-9 · 被引用次数：18 · 研究领域：Genetic and Kidney Cyst Diseases、Microtubule and mitosis dynamics、Protist diversity and phylogeny

Cilia are highly conserved eukaryotic organelles that protrude from the cell surface and are involved in sensory perception, motility, and signaling. Their proper assembly and function rely on the bidirectional intraflagellar transport (IFT) system, which involves motor proteins, including antegrade kinesins and retrograde dynein. Although the role of IFT-mediated transport in cilia has been extensively studied, recent research has highlighted the contribution of IFT-independent kinesins in ciliary processes. The coordinated activities and interplay between IFT kinesins and IFT-independent kinesins are crucial for maintaining ciliary homeostasis. In this comprehensive review, we aim to delve into the specific contributions and mechanisms of action of the IFT-independent kinesins in cilia. By shedding light on their involvement, we hope to gain a more holistic perspective on ciliogenesis and ciliopathies.