Higher pre‐pregnancy body mass index was associated with adverse pregnancy and perinatal outcomes in women with polycystic ovary syndrome after a freeze‐all strategy: A historical cohort study

作者：Xinyao Hu, Enqi Yan, Wenju Peng, Yueping Zhou, Lei Jin, Kun Qian · 发表于：Acta Obstetricia Et Gynecologica Scandinavica · 年份：2024 · DOI：10.1111/aogs.14771 · 被引用次数：10 · 研究领域：Ovarian function and disorders、Gestational Diabetes Research and Management、Pregnancy and preeclampsia studies

Abstract Introduction Previous studies have demonstrated that abnormal body mass index (BMI) is associated with adverse pregnancy outcomes in frozen–thawed embryo transfer cycles. However, the relationship between BMI and pregnancy and perinatal outcomes in patients with polycystic ovary syndrome (PCOS) remains unclear. Furthermore, whether a diagnosis of PCOS could result in adverse pregnancy and perinatal outcomes in women with different BMIs remains unknown. Material and methods A historical cohort study included 1667 women with PCOS and 12 256 women without PCOS after a freeze‐all policy between January 2016 and December 2020. The outcomes encompassed both pregnancy and perinatal outcomes. Multivariate logistic regression analysis and restricted cubic spline models were performed to eliminate confounding factors when investigating the relationship between BMI and different outcomes. Results After controlling for covariates, pregnancy outcomes were comparable between underweight women with PCOS and normal weight women with PCOS. However, overweight patients had a lower clinical pregnancy rate and an overall live birth rate. Furthermore, patients with obesity had a lower rate of multiple pregnancies but a higher rate of biochemical pregnancy than in the normal BMI group. Additionally, the restricted cubic spline models showed that as maternal BMI increased to 32 kg/m 2 , the clinical pregnancy rate and live birth rate after blastocyst transfer decreased, but the risks of pr...