A review on Zika vaccine development

作者：Zhe‐Yu Peng, Song Yang, Hong‐Zheng Lu, Lin‐Min Wang, Ni Li, Haiting Zhang, Si-Yu Xing, Yi‐Nan Du, Sheng‐Qun Deng · 发表于：Pathogens and Disease · 年份：2024 · DOI：10.1093/femspd/ftad036 · 被引用次数：31 · 研究领域：Mosquito-borne diseases and control、Virology and Viral Diseases、Viral Infections and Vectors

Zika virus (ZIKV), which belongs to the Flavivirus family, is mainly transmitted via the bite of Aedes mosquitoes. In newborns, ZIKV infection can cause severe symptoms such as microcephaly, while in adults, it can lead to Guillain‒Barré syndrome (GBS). Due to the lack of specific therapeutic methods against ZIKV, the development of a safe and effective vaccine is extremely important. Several potential ZIKV vaccines, such as live attenuated, inactivated, nucleic acid, viral vector, and recombinant subunit vaccines, have demonstrated promising outcomes in clinical trials involving human participants. Therefore, in this review, the recent developmental progress, advantages and disadvantages of these five vaccine types are examined, and practical recommendations for future development are provided.