Vaginal reconstruction by collagen scaffolds loaded with vaginal epithelial and smooth muscle cells in pigs

作者：Guangfeng Zhao, Yishan Dong, Ziying Ye, Simin Yao, Limin Wang, Yannan Zhao, Bing Chen, Dan Liu, Jianwu Dai, Yali Hu · 发表于：Biomaterials Science · 年份：2024 · DOI：10.1039/d3bm01611k · 被引用次数：9 · 研究领域：Tissue Engineering and Regenerative Medicine、Reconstructive Surgery and Microvascular Techniques、Molecular Biology Techniques and Applications

using the vaginal excision pig model. The results showed that the collagen scaffold loaded with vaginal epithelial and smooth muscle cells significantly promotes the reconstruction of the vagina compared with small intestinal submucosa (SIS) membrane or bare collagen scaffold. Notably, the reconstructed vaginal tissues exhibit remarkable similarity to their normal counterparts, encompassing not only the vaginal epithelium and smooth muscle but also the intricate networks of blood vessels and nerves. These compelling results underscore the feasibility of a tissue engineering approach in vaginal reconstruction, offering promising prospects for improving the quality of life in affected individuals.