Characteristics, management, and outcomes in women and men with congestive heart failure in 40 countries at different economic levels: an analysis from the Global Congestive Heart Failure (G-CHF) registry

作者：Marjan Walli-Attaei, Philip G. Joseph, Isabelle Johansson, Karen S Sliwa, Eva Lonn, Aldo Pietro Maggioni, Lisa Marie Mielniczuk, Heather Joan Ross, Kamilu Musa Karaye, Camilla Hage, Nana V. Pogosova, Alex Grinvalds, Tara McCready, John J.V. McMurray, Salim Yusuf · 发表于：The Lancet Global Health · 年份：2024 · DOI：10.1016/s2214-109x(23)00557-0 · 被引用次数：50 · 研究领域：Heart Failure Treatment and Management、Acute Myocardial Infarction Research、Cardiovascular Function and Risk Factors

BACKGROUND: There is a paucity of data on the clinical characteristics, management, and outcomes of women compared with men with heart failure in low-income and middle-income countries compared with high-income countries. We examined sex differences in risk factors, clinical characteristics, and treatments, and prospectively assessed the risk of heart failure hospitalisation and mortality in patients with heart failure in 40 high-income, middle-income, and low-income countries. METHODS: Participants aged 18 years or older with heart failure were enrolled from Dec 20, 2016, to Sept 9, 2020 in the prospective Global Congestive Heart Failure (G-CHF) study from 257 centres in 40 high-income, middle-income, and low-income countries. Participants were followed up until May 25, 2023. We recorded the demographic characteristics, medical history, and treatments of participants. We prospectively recorded data on heart failure hospitalisation and mortality by sex in the overall study, according to country economic status, and according to level of left ventricular ejection fraction (LVEF). FINDINGS: 23 341 participants (9119 [39·1%] women and 14 222 [60·1%] men) were recruited and followed up for a mean of 2·6 years (SD 1·4). The mean age of women in the study was 62 years (SD 17) compared with 64 years (14) in men. Fewer women than men had an LVEF of 40% or lower (51·7% women vs 66·2% men). By contrast, more women than men had an LVEF of 50% or higher (33·2% women vs 18·6% men). Hypert...