A 10-micrometer-thick nanomesh-reinforced gas-permeable hydrogel skin sensor for long-term electrophysiological monitoring

作者：Zongman Zhang, Jiawei Yang, Haoyang Wang, Chunya Wang, Yuheng Gu, Yumiao Xu, Sunghoon Lee, Tomoyuki Yokota, Hossam Haick, Takao Someya, Yan Wang · 发表于：Science Advances · 年份：2024 · DOI：10.1126/sciadv.adj5389 · 被引用次数：268 · 研究领域：Advanced Sensor and Energy Harvesting Materials、Tactile and Sensory Interactions、Nanomaterials and Printing Technologies

Hydrogel-enabled skin bioelectronics that can continuously monitor health for extended periods is crucial for early disease detection and treatment. However, it is challenging to engineer ultrathin gas-permeable hydrogel sensors that can self-adhere to the human skin for long-term daily use (>1 week). Here, we present a ~10-micrometer-thick polyurethane nanomesh-reinforced gas-permeable hydrogel sensor that can self-adhere to the human skin for continuous and high-quality electrophysiological monitoring for 8 days under daily life conditions. This research involves two key steps: (i) material design by gelatin-based thermal-dependent phase change hydrogels and (ii) robust thinness geometry achieved through nanomesh reinforcement. The resulting ultrathin hydrogels exhibit a thickness of ~10 micrometers with superior mechanical robustness, high skin adhesion, gas permeability, and anti-drying performance. To highlight the potential applications in early disease detection and treatment that leverage the collective features, we demonstrate the use of ultrathin gas-permeable hydrogels for long-term, continuous high-precision electrophysiological monitoring under daily life conditions up to 8 days.