Lactate administration improves laboratory parameters in murine models of iron overload

作者：Wei Liu, Yue Wu, Huaiqing Wei, Juan Ma, Wenya Feng, Qiuyuan Yang, Shuping Zhang, Tomas Ganz, Sijin Liu · 发表于：Blood · 年份：2024 · DOI：10.1182/blood.2023021695 · 被引用次数：4 · 研究领域：Iron Metabolism and Disorders、Hemoglobinopathies and Related Disorders、Trace Elements in Health

ABSTRACT: Current iron overload therapeutics have inherent drawbacks including perpetuated low hepcidin. Here, we unveiled that lactate, a potent hepcidin agonist, effectively reduced serum and hepatic iron levels in mouse models of iron overload with an improved erythropoiesis in β-thalassemic mice.