The Tuberculosis Sentinel Research Network (TB-SRN) of the International epidemiology Databases to Evaluate AIDS (IeDEA): protocol for a prospective cohort study in Africa, Southeast Asia and Latin America

作者：Leslie A. Enane, Stephany N. Duda, Thida Chanyachukul, Carolyn Bolton‐Moore, Neelima Navuluri, Eugène Messou, Nana Mbonze, LaQuita R McDade, Marina C. Figueiredo, Jeremy A. Ross, Denise Evans, Lameck Diero, Robert Akpata, Natalia Zotova, Aimee Freeman, Marie Flore Pierre, Dhanushi Rupasinghe, Marie Ballif, Helen Byakwaga, Nathalie De Castro, Martine Tabala, Timothy R. Sterling, Annette H. Sohn, Lukas Fenner, Kara Wools‐Kaloustian, Armel Poda, Marcel Yotebieng, Robin Huebner, Olivier Marcy · 发表于：BMJ Open · 年份：2024 · DOI：10.1136/bmjopen-2023-079138 · 被引用次数：10 · 研究领域：Tuberculosis Research and Epidemiology、Pneumocystis jirovecii pneumonia detection and treatment、Diagnosis and treatment of tuberculosis

INTRODUCTION: Tuberculosis (TB) is a leading infectious cause of death globally. It is the most common opportunistic infection in people living with HIV, and the most common cause of their morbidity and mortality. Following TB treatment, surviving individuals may be at risk for post-TB lung disease. The TB Sentinel Research Network (TB-SRN) provides a platform for coordinated observational TB research within the International epidemiology Databases to Evaluate AIDS (IeDEA) consortium. METHODS AND ANALYSIS: This prospective, observational cohort study will assess treatment and post-treatment outcomes of pulmonary TB (microbiologically confirmed or clinically diagnosed) among 2600 people aged ≥15 years, with and without HIV coinfection, consecutively enrolled at 16 sites in 11 countries, across 6 of IeDEA's global regions. Data regarding clinical and sociodemographic factors, mental health, health-related quality of life, pulmonary function, and laboratory and radiographic findings will be collected using standardised questionnaires and data collection tools, beginning from the initiation of TB treatment and through 12 months after the end of treatment. Data will be aggregated for proposed analyses. ETHICS AND DISSEMINATION: Ethics approval was obtained at all implementing study sites, including the Vanderbilt University Medical Center Human Research Protections Programme. Participants will provide informed consent; for minors, this includes both adolescent assent and the conse...