Unveiling the landscape of cytokine research in glioma immunotherapy: a scientometrics analysis

作者：Hongyu Zhang, Ying Chen, Xinzhan Jiang, Qiang Gu, Jiahao Yao, Xuefeng Wang, Jianghua Wu · 发表于：Frontiers in Pharmacology · 年份：2024 · DOI：10.3389/fphar.2023.1333124 · 被引用次数：12 · 研究领域：Glioma Diagnosis and Treatment、Radiomics and Machine Learning in Medical Imaging、Cancer Immunotherapy and Biomarkers

Background: Cytokines modulate the glioma tumor microenvironment, influencing occurrence, progression, and treatment response. Strategic cytokine application may improve glioma immunotherapy outcomes. Gliomas remain refractory to standard therapeutic modalities, but immunotherapy shows promise given the integral immunomodulatory roles of cytokines. However, systematic evaluation of cytokine glioma immunotherapy research is absent. Bibliometric mapping of the research landscape, recognition of impactful contributions, and elucidation of evolutive trajectories and hot topics has yet to occur, potentially guiding future efforts. Here, we analyzed the structure, evolution, trends, and hotspots of the cytokine glioma immunotherapy research field, subsequently focusing on avenues for future investigation. Methods: This investigation conducted comprehensive bibliometric analyses on a corpus of 1529 English-language publications, from 1 January 2000, to 4 October 2023, extracted from the Web of Science database. The study employed tools including Microsoft Excel, Origin, VOSviewer, CiteSpace, and the Bibliometrix R package, to systematically assess trends in publication, contributions from various countries, institutions, authors, and journals, as well as to examine literature co-citation and keyword distributions within the domain of cytokines for glioma immunotherapy. The application of these methodologies facilitated a detailed exploration of the hotspots, the underlying knowledge...